BrachyView: initial preclinical results for a real-time in-body HDR PBT source tracking system with simultaneous TRUS image fusion.

BrachyView: initial preclinical results for a real-time in-body HDR PBT source tracking system with simultaneous TRUS image fusion. Phys Med Biol. 2019 Feb 26;: Authors: Alnaghy S, Cutajar DL, Safavi-Naeini M, George S, Howie A, Bece A, Bucci JA, Jakubek J, Pospisil S, Lerch MLF, Petasecca M, Rozenfeld AB Abstract A prototype in-body gamma camera system with integrated trans-rectal ultrasound (TRUS) and associated real-time image acquisition and analysis software was developed for intraoperative source tracking in high dose rate (HDR) brachytherapy. The accuracy and temporal resolution of the system was validated experimentally using a deformable tissue-equivalent prostate gel phantom and a full clinical HDR treatment plan. The BrachyView system was able to measure 78% of the 200 source positions with an accuracy of better than 1 mm. A minimum acquisition time of 0.28 s/frame was required to achieve this accuracy, restricting dwell times to a minimum of 0.3 s. Additionally, the performance of the BrachyView-TRUS fusion probe for mapping the spatial location of the tracked source within the prostate volume was evaluated. A global coordinate system was defined by scanning the phantom with the probe in situ using a CT scanner and was subsequently used for co-registration of the BrachyView and TRUS Fields of View (FoVs). TRUS imaging was used to segment the prostate volume and reconstruct it into a three-dimensional image. Fusion of the estimated source loca...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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Abstract The purpose of this article was to report the treatment effect of image-guided high-dose-rate interstitial brachytherapy boost in the radical radiotherapy for a huge metastatic carcinoma of cervical lymph nodes from an unknown primary site. The patient was a 75-year-old male. A diagnostic biopsy showed metastatic squamous cell carcinoma and the tumour size was 7.5×6.5×11.5cm3 before treatment (N3; AJCC 7th). After external beam radiotherapy with a dose of 60Gy in 30 fractions, the residual tumour (6.2×4.7×6.0cm3) was treated with image-guided high-dose-rate interstitial brachythera...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Researchers at Western University, London Health Sciences Centre, and Lawson Health Research Institute, all in Canada, have developed and tested a new 3D ultrasound system. Designed to improve the accuracy of interstitial brachytherapy, a technique i...
Source: Medgadget - Category: Medical Devices Authors: Tags: Ob/Gyn Oncology Source Type: blogs
Conclusion: The efficacy of brainstem gliomas—treated with CyberKnife is efficacious with mild toxicity. Introduction Brainstem gliomas (BSGs) account for 5–15% of brain tumors and more likely happen in children (1). BSGs constitute at least 20% of childhood brain neoplasms (2), and the peak age is 7–9 years. In contrast, BSGs is rare in the adult population and account for only 1.5–2.5% of brain glioma, with a peak age of 40–70 years (1). Diffuse intrinsic pontine glioma(DIPG) was the most common type of BSG is that could invade the whole brainstem including midbrain, pons as well as me...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Generally, minimally invasive techniques are used for diagnosis and treatment. Compared to open surgery, these procedures are aimed to reduce the risk of surrounding tissues injury and lead to less trauma and shorter recovery time (Slakey  et al. 2013). Percutaneous biopsy in the liver is a minimally invasive procedure where a needle is used to remove tissue samples for histology-based diagnosis. Needle insertion is also performed in therapeutic procedures such as in prostate brachytherapy and in liver tumor thermal ablation (radi ofrequency, microwave or cryo ablation).
Source: Medical Image Analysis - Category: Radiology Authors: Source Type: research
Generally, minimally invasive techniques are used for diagnosis and treatment. Compared to open surgery, these procedures are aimed to reduce the risk of surrounding tissues injury and lead to less trauma and shorter recovery time (Slakey, Simms et al. 2013). Percutaneous biopsy in the liver is a minimally invasive procedure where a needle is used to remove tissue samples for histology-based diagnosis. Needle insertion is also performed in therapeutic procedures such as in prostate brachytherapy and in liver tumor thermal ablation (radiofrequency, microwave or cryo ablation).
Source: Medical Image Analysis - Category: Radiology Authors: Source Type: research
Abstract Imaging has probably been the most important driving force for the development of brachytherapy treatments the last 20 years. Due to implementation of three-dimensional imaging, brachytherapy is nowadays a highly accurate and reliable treatment option for many cancer patients. To be able to optimize the dose distribution in brachytherapy the anatomy and the applicator(s) or sources should be correctly localised in the images. For computed tomography (CT) the later criteria is easily fulfilled for most brachytherapy sites. However, for many sites, like cervix and prostate, CT is not optimal for delineation...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Conclusion: Current literature suggests the majority of choroidal melanoma recurrences occur within 5 years following treatment. However, this case of recurrence 10 years after brachytherapy emphasizes the importance of life-long ophthalmic care for these patients. Additionally, this case demonstrates the possibility of a rare recurrence at a prior biopsy site.Ocul Oncol Pathol 2018;4:225-229
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
CONCLUSIONS: The MRI/US fusion demonstrated greater prostate volume compared to standard CT/US based planning likely due to the better resolution of the prostate apex. Furthermore, rectal dose was underestimated with CT vs. MRI based planning. Additional study is required to assess long-term clinical implications of disease control and effects on long-term toxicity, especially as related to the rectum and urinary sphincter. MRI/US intraoperative fusion may improve prostate dosimetry while sparing the rectum and urethra, potentially impacting disease control and late toxicity. PMID: 28951749 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
CONCLUSIONS: Although improving the IO preimplant and postimplant dosimetry improved dosimetry on Day 30, the BR-free rate was not dependent on any dosimetric parameter. Unpredictable factors such as intraprostatic seed migration and IO factors, prevented the accurate prediction of Day 30 dosimetry. PMID: 28951748 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
CONCLUSION: Our data suggest that CXB can reduce local regrowth to 11% compared with around 30% after EBCRT alone. Organ preservation of 62% achieved was higher than reported in most published watch and wait studies. Advances in knowledge: CXB is a promising treatment option to avoid salvage surgery for local regrowth, which can improve the chance of organ preservation in patients who are not suitable for or refuse surgery. PMID: 28937269 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
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