Study traces the origins of Chikungunya in Brazil

(Columbia University's Mailman School of Public Health) New evidence suggests that Chikungunya virus arrived in Brazil at least one year earlier than it was detected by public health surveillance systems. Scientists at the Center for Infection and Immunity (CII) at the Columbia Mailman School of Public Health and Funda ç ã o Oswaldo Cruz published their findings in the journal Scientific Reports.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Robert T. Schoen Chikungunya fever (CHIKF) is an emerging viral infection that has spread widely, along with its Aedes vectors, throughout the tropics and beyond, causing explosive epidemics of acute illness and persistent disabling arthritis. The rheumatic symptoms associated with chikungunya virus (CHIKV) infection include polyarthralgia, polyarthritis, morning stiffness, joint edema, and erythema. Chronic CHIK arthritis (CCA) often causes severe pain and associated disability. The pathogenesis of CCA is not well understood. Proposed hypotheses include the persistence of a low level of replicating virus in the joint...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Publication date: Available online 21 March 2019Source: Antiviral ResearchAuthor(s): L. Pezzi, C.B. Reusken, S.C. Weaver, J.F. Drexler, M. Busch, A.D. LaBeaud, M.S. Diamond, N. Vasilakis, M.A. Drebot, A.M. Siqueira, G.S. Ribeiro, A. Kohl, M. Lecuit, L.F.P. Ng, P. Gallian, X. de Lamballerie, GloPID-R Chikungunya, O'nyong-nyong and Mayaro virus Working Group, S. Boyer, P. Brasil, M. Diallo, A.B. FaillouxAbstractThe GloPID-R (Global Research Collaboration for Infectious Disease Preparedness) Chikungunya (CHIKV), O'nyong-nyong (ONNV) and Mayaro virus (MAYV) Working Group is investigating the natural history, epidemiology and m...
Source: Antiviral Therapy - Category: Virology Source Type: research
Authors: Bhat SM, Mudgal PP, N S, Arunkumar G Abstract INTRODUCTION: Chikungunya disease has undergone a phenomenal transition in its status from being recognized as a sporadic infection to acquiring a global prominence over the last couple of decades. The causative agent behind the explosive worldwide epidemics is the re-emerging pathogen, Chikungunya virus (CHIKV). Areas covered: The current review discusses all the possible avenues of antiviral research towards combating CHIKV infection. Aspects of antiviral drug discovery such as antiviral targets, candidate molecules screened, and the various criteria to be a ...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Authors: Carissimo G, Ng LFP Abstract Since its re-emergence in 2006, Chikungunya has been a major health concern in endemic areas. Transmitted by Aedes mosquitoes to mammalian hosts, Chikungunya leads to persistent debilitating symptoms in a high proportion of symptomatic human cases. In this review, we present several tools on the mosquito vector side as well as on the mammalian side that have been used to advance research on Chikungunya transmission and immunopathogenesis. These tools lead to key understandings of viral replication in both hosts, and innate and adaptive responses mediating virus clearance and pa...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Abstract Aedes aegypti mosquitoes transmit pathogens such as yellow fever, dengue, Zika, and chikungunya viruses to millions of human hosts annually [1]. As such, understanding Ae. aegypti courtship and mating biology could prove crucial to the success of disease control efforts that target reproduction. Potentially to communicate reproductive fitness [2,3], mosquito males and females harmonize their flight tones prior to mating in a behavior known as harmonic convergence (HC) [4]. Furthermore, after mating or treatment with extracts from male accessory glands (MAG), which make seminal fluid molecules, female Ae. ...
Source: Current Biology - Category: Biology Authors: Tags: Curr Biol Source Type: research
What are the challenges and implications to public health presented by the rising incidence in the Americas of arboviral infections such as dengue, zika, yellow fever, and chikungunya?American Journal of Public Health
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: Public Health & Prevention Journal Article Source Type: news
Conclusions/SignificanceThe IMS is an automated, easy to use, novel diagnostic tool that allows rapid differentiation between common causes of febrile illness in Southeast Asia.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Abstract BACKGROUND: In November 2011, a government hospital physician in Shibganj sub-district of Bangladesh reported a cluster of patients with fever and joint pain or rash. A multi-disciplinary team investigated to characterize the outbreak; confirm the cause; and recommend control and prevention measures. METHODS: Shibganj's residents with new onset of fever and joint pain or rash between 1 September and 15 December 2011 were defined as chikungunya fever (CHIKF) suspect cases. To estimate the attack rate, we identified 16 outpatient clinics in 16 selected wards across 16 unions in Shibganj and searched fo...
Source: Pain Physician - Category: Anesthesiology Authors: Tags: PLoS One Source Type: research
Abstract In 2016, a chikungunya virus (CHIKV) outbreak was reported in Mandera, Kenya. This was the first major CHIKV outbreak in the country since the global reemergence of this virus in Kenya in 2004. We collected samples and sequenced viral genomes from this outbreak. All Kenyan genomes contained two mutations, E1:K211E and E2:V264A, recently reported to have an association with increased infectivity, dissemination, and transmission in the Aedes aegypti vector. Phylogeographic inference of temporal and spatial virus relationships showed that this variant emerged within the East, Central, and South African linea...
Source: Am J Trop Med Hyg - Category: Infectious Diseases Authors: Tags: Am J Trop Med Hyg Source Type: research
Conclusions: The inactivation profiles of different alphavirus members vary considerably, even within the Semliki Forest Complex. However, robust dedicated viral inactivation/removal procedures commonly used in the plasma product industry are effective in inactivating or removing MAYV and CHIKV.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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