Acute pancreatitis in a patient with glycogen storage disease type 1a

A female child, 13 months of age, presented to our institution and was of short stature (68.2  cm;–2.5 standard deviation [SD]) and low weight (7655 g,–1.5 SD). She had hypertriglyceridemia (triglyceride (TG): 1100 mg/dL, total cholesterol (TC): 237 mg/dL) with mild hepatomegaly and did not present with hypoglycemia. We initially suspected a lipid metabolism disorder. At 19 months, t he child was admitted to our institution again because of a viral infection. She had hypoglycemia (64 mg/dL), hyperlactatemia (84.7 mg/dL), hyperuricemia (13.5 mg/dL), hypertriglyceridemia (1124 mg/dL), and exacerbated hepatomegaly.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Letter to the Editor Source Type: research

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This study determined, if increased intrauterine oxidative stress (IUOx) affects adiposity, glucose and cholesterol metabolism in adult Ldlr−/−xSod2+/+ offspring from crossing male Ldlr−/−xSod2+/+ mice with Ldlr−/−xSod2 ± dams (IUOx) or Ldlr−/−xSod2 ± males with Ldlr−/−xSod2+/+ dams (control). At 12 weeks of age mice received Western diet for an additional 12 weeks. Adult male IUOx offspring displayed lower body weight and reduced adiposity associated with improved glucose tolerance compared to controls. Reduced weight gain in IUO...
Source: Redox Biology - Category: Biology Source Type: research
In this study, we present an electrochemical method to detect SMEnzyme concentration that is more sensitive and much faster than currently available commercial assays. For detection and the amplification of the SMEnzyme signal, methylene blue (MB)-encapsulated sphingomyelin (SM)-based liposome with 50 % cholesterol was synthesized via sonication method. Then the target SMEnzyme causes the free release of the MB from the MB-liposome formulation which can be detected on GCE||Au-PAni/N,S-GQDs electrode, prepared via interfacial polymerization and then self-assembly approach. The change of SM to gel state bilayer with increasi...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Conclusion: The results of this systematic review provide evidence on the benefits of zinc supplementation on lipid profiles in obese individuals. However, new intervention studies are needed to elucidate the function of the nutrient in protection against disorders related to lipid metabolism, as well as the standardization of the type, dose, and time of zinc supplementation.
Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Publication date: Available online 18 September 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Shih-Wei Lai, Yu-Hung Kuo, Chia-Wei Fang, Kuan-Fu Liao
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
CONCLUSIONS Long-term HFD in mice resulted in left ventricular hypertrophy, interstitial fibrosis, dysregulation of RAS, and abnormal expression of ICD proteins compared with ND mice, but did not affect the distribution of cardiomyocyte ICD proteins. Long-term HFD resulted in cardiac remodeling and altered expression of ICD proteins through RAS activation. PMID: 31523052 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionBlood biomarkers unveil intersections among unemployment, immigration and gender. This study provides evidence on biological pathways of unemployment on the likelihood of common chronic diseases, inflammation and potential malnutrition with some increased vulnerabilities in unemployed immigrants, and particularly in unemployed immigrant women.
Source: Archives of Public Health - Category: International Medicine & Public Health Source Type: research
AbstractAimsTo observe the effects of saxagliptin on the expression of mitogen-activated protein kinase 38 (p38MAPK), nephrin and podocin in renal tissue in type 2 diabetic (T2DM) rats, and to explore the possible mechanism of its renal protection.MethodsForty-eight male Sprague –Dawley rats were used for the study and divided into four different groups: normal controls (Group NC), DM controls (Group DM), DM + glibenclamide (Group Su) and DM + saxagliptin (Group Sa). The day drug administration started was defined as week 0. After 12 weeks, hemoglobin A1c (HbA1c) , total cholesterol (...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Publication date: Available online 16 September 2019Source: European Journal of RadiologyAuthor(s): Liang Zhu, Hua-dan Xue, Wen Zhang, Qiang Wang, Bei Tan, Ya-min Lai, Wei-yang Zheng, Patrick Asbach, Bernd Hamm, Timm Denecke, Zheng-yu JinAbstractPurposeTo evaluate the imaging pattern of pancreaticobiliary lesions in patients with treated type 1AIP, to determine the incidence of disease relapse and malignancy, and to identify the risk factors.MethodThe institutional review board approval was acquired. All patients gave written informed consent. From a prospective clinico-radiological database since 2012, consecutive patient...
Source: European Journal of Radiology - Category: Radiology Source Type: research
While medication can reduce cholesterol levels, researchers say people with a family history of hypercholesterolemia are still at a higher risk for cardiovascular events.
Source: Health News - - Category: Consumer Health News Source Type: news
A new Mendelian randomization study shows the large benefits that could be achieved from small reductions in cholesterol and blood pressure if maintained over a lifetime.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
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