Stiff Person Syndrome and Type 1 Diabetes Mellitus: a Case of the Chicken or the Egg?

We present the case of a 23-year-old non-diabetic, insulin-na ïve woman with known SPS who was hospitalized for SPS-related symptomatology. The patient quickly developed type 1 diabetes mellitus (T1DM) with unexpectedly large insulin requirements. To our knowledge, there are no other reports describing rapid T1DM development during an acute hospitalization fo r SPS and fewer than 5 case reports describing the association of SPS with extreme insulin resistance. Our case highlights the key clinical features, pathology, and pathogenesis of both SPS and T1DM and explores the relationship between the two disease processes.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research