Selective interaction of triple-negative breast cancer cells with netrin-4 correlates with CD146 expression

Introduction: Netrins are a family of laminin-related extracellular matrix proteins which includes in humans the secreted netrin-1 and netrin-4. Both family members are not only involved in normal tissue development, but also in different types of malignancies. In primary breast cancer a direct correlation exists between the expression of netrin-1, the state of the disease and the generation of distant metastases. Netrin-4 expression in invasive breast tumors is a strong prognostic marker for overall survival.

Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 19, 2019 Category: OBGYN Authors: Helen Burow, Christina Barbara Walter, Sara Brucker, Gerd Klein Tags: Oral Poster at Breakfast 9 – Breast Source Type: research