Citalopram-Associated Alopecia: A Case Report and Brief Literature Review.

Citalopram-Associated Alopecia: A Case Report and Brief Literature Review. Curr Drug Saf. 2019 Feb 14;: Authors: Hekmatjah J, Tareen K, Tareen RS Abstract BACKGROUND: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer improved side effect profile compared to older treatments, which improve patient adherence and quality of life. CASE REPORT: Here we discuss a case of an uncommon, but distressing side effect of citalopram. A 76-year old woman was referred to the psychiatry clinic for bizarre behavior. Patient was diagnosed with behavioral variant frontotemporal dementia, and was started on citalopram 20 mg and aripiprazole 5 mg daily. At 3.5 months the patient complained of diffuse hair thinning on her scalp. Citalopram was considered the offending agent and was discontinued. Within a few months, the patient regained most of her hair. Although drug induced alopecia is common among other SSRIs, it is relatively rare with citalopram. Early recognition, withdrawal of offending agent, and reassurance to the patient that hair loss is reversible can help alleviate patient distress and avoid relapse. PMID: 30767750 [PubMed - as supplied by publisher]
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research

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Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Today, I'll point out an analysis from the SENS Research Foundation that covers the approach to selective destruction of senescent cells taken by one of the newly formed biotech startups in the space, Senolytic Therapeutics. This field is hot because it is now well proven that senescent cells are the enemy. They are one of the root causes of aging, accumulating with age to degrade tissue function via the secretion of inflammatory signal molecules. Senescent cells actively maintain an aged, inflamed state of metabolism, resulting in the development of age-related disease and increased mortality. Senescent cells do se...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Cerebral small vessel disease (SVD) is recognized to be the leading cause of vascular dementia. Although the most cases are sporadic, familial monogenic causes have been identified. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), a recessive form of heritable SVD, is caused by a mutation in the HtrA serine peptidase 1 (HTRA1) gene, and characterized by progressive neurological deterioration along with early baldness and severe spondylosis [1].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Tags: Letter to the Editor Source Type: research
This article, unfortunately paywalled, is interesting to note as a mark of the now increasingly energetic expansion of commercial efforts in longevity science. David Sinclair has been building a private equity company to work in many areas relevant to this present generation of commercial longevity science; while I'm not sold on his primary research interests as the basis for meaningful treatments for aging, he is diversifying considerably here, including into senolytics, the clearance of senescent cells demonstrated to produce rejuvenation in animal studies. This sort of approach to business mixes aspects of investing and...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In the several decades since the need for dietary zinc was discovered, it has proven to be far more important to overall health than initially thought. And deficiency is proving to be common. You may recall that the phytates of wheat and grains block nearly all absorption of dietary zinc, along with blocking iron, calcium, and magnesium (all positively-charged cations). Just as iron deficiency anemia with hemoglobin values of 7 or 8 g/dl resistant to iron supplementation commonly develops in grain-consuming populations, so a parallel zinc deficiency also develops (although not well reflected by blood levels of zinc, which ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle autoimmune gastrointestinal gluten gluten-free grain grain-free grains hormonal Inflammation phytates rash zinc Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We report a patient who developed an early-onset cognitive decline with genetic, cerebrospinal fluid biomarker and structural and functional neuroimaging studies consistent with Alzheimer's disease. Eight years into her disease, she developed severe, repetitive hair-pulling behavior leading to marked hair loss, along with other repetitive and "frontal" behaviors. Selective serotonin reuptake inhibitors (SSRIs) were ineffective in controlling her hair-pulling behavior, which subsequently responded to quetiapine 150 mg/day. This patient and a review of the literature suggest that trichotillomania may be a co...
Source: Case Reports in Psychiatry - Category: Psychiatry Tags: Case Rep Psychiatry Source Type: research
Conclusions: The mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers.
Source: Neurology - Category: Neurology Authors: Tags: Stroke in young adults, Other cerebrovascular disease/ Stroke, CADASIL, Vascular dementia ARTICLE Source Type: research
A 26-year-old Turkish patient presented with progressive spastic gait since age 20 years and premature alopecia. Cerebral and spinal MRI revealed diffuse supra- and infratentorial leukoencephalopathy with recurrent subclinical subcortical infarcts and multiple disk herniations with cervical myelopathy (figure). Targeted panel-sequencing revealed a novel homozygous splice site mutation (c.1005+1G>T; p.?) in HTRA1, which is known to cause CARASIL (cerebral autosomal-recessive arteriopathy with subcortical infarcts and leukoencephalopathy),1 mostly described in Asians so far.
Source: Neurology - Category: Neurology Authors: Tags: Stroke in young adults, Vascular dementia RESIDENT AND FELLOW SECTION Source Type: research
In this study we expanded the study by investigating associations of the rest blood parameters with age, and associations between generations, aiming to seek candidate factors associated with familial longevity. Associations of blood parameters in centenarians (CEN) with their first generation of offspring (F1) and F1 spouses (F1SP) were analyzed. In this study, using association and further comparison analyses we identified several blood parameters that may contribute to longevity. First, total cholesterol (TC) and triglyceride (TG) increased with age until 80 years, but decreased in centenarians, indicating that l...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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