Drug-induced idiosyncratic acute liver failure: A challenging and distressing scenario.

Drug-induced idiosyncratic acute liver failure: A challenging and distressing scenario. Curr Drug Saf. 2019 Feb 14;: Authors: Colaci CS, Mendizabal M, Bessone F Abstract Idiosyncratic drug induced liver injury (DILI) is a rare adverse event to drugs that occasionally leads to severe liver damage, being one of the leading causes of acute liver failure (ALF) in developed countries. DILI is largely a diagnosis of exclusion. Thus, careful history of drug taking and ruling out other competing etiologies is mandatory given that DILI can present with an extremely variable phenotype. Several prognostic scores have been developed to promptly identify patients with potential risk of developing ALF. New biomarkers to diagnose and predict DILI evolution are under study and hopefully we will benefit from these novel tools in the near future. PMID: 30767751 [PubMed - as supplied by publisher]
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research