Recent advances of anti-cancer therapies including the use of cell-penetrating peptides.

Recent advances of anti-cancer therapies including the use of cell-penetrating peptides. Curr Opin Pharmacol. 2019 Feb 13;47:8-13 Authors: Klimpel A, Lützenburg T, Neundorf I Abstract Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bioavailability. During the last thirty years, cell-penetrating peptides (CPPs) have extensively been studied as efficient vehicles for several classes of cargos, and the development of novel therapeutic applications including CPPs has gained a major role in current cancer research. This review summarizes recent trends in CPP-mediated cargo delivery with a future impact on anti-cancer therapy. PMID: 30771730 [PubMed - as supplied by publisher]
Source: Current Opinion in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Opin Pharmacol Source Type: research