Contemporary Issues in Quantitative Myocardial Perfusion CMR Imaging

AbstractPurpose of ReviewThis review highlights the development and application of quantitative myocardial perfusion by cardiac magnetic resonance (CMR) and discusses recent innovations in this area.Recent FindingsFirst pass, contrast-enhanced CMR can accurately quantify myocardial perfusion in order to diagnose obstructive coronary artery disease and microvascular dysfunction. Quantitative analysis conveys additional prognostic information beyond other CMR findings. New, fully automated techniques may aid standardization of methods across centers.SummaryCMR quantitative perfusion has robust performance for the diagnosis of obstructive coronary disease and microvascular dysfunction and conveys prognostic information. Adoption of automated post-processing and standardized protocols will further strengthen CMR in its position as the modality of choice for the evaluation of possible myocardial ischemia.
Source: Current Cardiovascular Imaging Reports - Category: Radiology Source Type: research

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The objective of this article is to document whether DIRT can accurately map the position of the perforators and measure their influence on the perfusion of the flap in order to select the best perforators to improve the outcome of breast reconstructions with free DIEP flaps. A systematic review of the literature published between January 1998 and November 23th 2018 was conducted regarding the possible benefit of dynamic infrared thermography (DIRT) in DIEP-flap breast reconstructions.The databases PubMed and Web of Science were used to search for qualified articles. Inclusion criteria were women who underwent a breast rec...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Objectives: Left ventricular (LV) hypertrophy in resistant hypertensive patients is associated with a reduced intramyocardial perfusion. Renal sympathetic denervation (RDN) has been shown to reduce blood pressure (BP) and sympathetic tone. We aimed to prospectively investigate the effect of RDN on functional myocardial parameters and myocardial perfusion reserve (MPR) using cardiac magnetic resonance imaging (cMRI) in patients with resistant hypertension. Methods: A total of 15 resistant hypertensive patients (11 male individuals, mean age 62±13 y) were included. Adenosine stress-induced cMRI was perform...
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research
Cervical spondylosis may lead to spinal cord compression, poor vascular perfusion, and ultimately cervical myelopathy. The process whereby chronic compression may cause spinal cord damage has not been fully understood. However, multiple mechanisms such as inflammation, apoptosis, and vascular variations, are thought to be responsible for the neuronal loss, axonal degeneration, and myelin impairment seen in cervical spondylotic myelopathy (CSM). Studies reported a beneficial effect of renin-angiotensin system (RAS) blockers in the central nervous system, particularly in brain inflammation and stroke, but data on their influ...
Source: The Spine Journal - Category: Orthopaedics Authors: Source Type: research
In patients with suspected or known coronary artery disease (CAD) the presence of stress-induced myocardial ischemia is still considered an indication for invasive coronary angiography (ICA) and, if needed, coronary revascularization. This management is based on the “dogma” that in patients with CAD the presence and extent of inducible myocardial ischemia predicts adverse cardiovascular events, and that the reduction of ischemic burden would have a favourable impact on patients' outcome [1]. These considerations have been further reinforced by recent data d emonstrating the extremely low diagnostic yield of ICA...
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Authors: Buka D, Dvořák J, Richter I, Škrobánek P, Buchler T, Melichar B Abstract There is a growing corpus of evidence indicating that anti-VEGF therapy may normalize the abnormal tumor vasculature with the potential to re-program the tumor immune microenvironment to a more immunosupportive profile. Tumor vessel normalization increases tumor perfusion, and, consequently, oxygen and nutrient supply, and thus can be assumed to improve the general response to anticancer immunotherapy. The increased antitumor immunity responses seen following anti-VEGF therapy may also be associated with the inhi...
Source: Acta Medica: Hradec Kralove - Category: General Medicine Tags: Acta Medica (Hradec Kralove) Source Type: research
Authors: Ding C, Han F, Xiang H, Wang Y, Dou M, Xia X, Li Y, Zheng J, Ding X, Xue W, Tian P Abstract The mechanisms by which prostaglandin E2 receptor 4 (EP4) protects against renal ischemia‑reperfusion (I/R) injury (IRI) remain to be fully elucidated. In the present study, the protective effects of EP4 signaling on renal mitochondria and against renal IRI, as well as the underlying mechanisms, were investigated. A rat model of renal IRI was established. The right kidney was separated without damaging the artery clip, and the renal blood perfusion was then restored after 60 min. One group of animals was trea...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Acute Kidney Injury (AKI) is an important complication after cardiac surgery and increases the morbidity and mortality of patients while increasing health care costs.1 AKI occurs in up to 30% of patients undergoing cardiac surgery, and dialysis is necessary in 1% to 2%.2 Preoperative risk factors for AKI in these patients include age, diabetes, anemia, renal insufficiency, contrast exposure, atrial fibrillation, and lower ejection fraction. Intraoperative factors include cardiopulmonary bypass (CPB) time, nonpulsatile flow, lowest hematocrit on pump, renal perfusion pressure, inflammatory response, and blood transfusion.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
Publication date: Available online 21 August 2019Source: Redox BiologyAuthor(s): Bumsoo Ahn, Nataliya Smith, Debra Saunders, Rojina Ranjit, Parker Kneis, Rheal A. Towner, Holly Van RemmenAbstractMitochondrial dysfunction, reactive oxygen species (ROS) and oxidative damage have been implicated to play a causative role in age-related skeletal muscle atrophy and weakness (i.e. sarcopenia). Mice lacking the superoxide scavenger CuZnSOD (Sod1−/−) exhibit high levels of oxygen-derived radicals and oxidative damage, associated with neuronal and muscular phenotypes consistent with sarcopenia. We used magnetic resonance...
Source: Redox Biology - Category: Biology Source Type: research
Heart failure with preserved ejection fraction (HFpEF) is frequently accompanied by comorbidities and a systemic proinflammatory state, resulting in coronary microvascular dysfunction (CMD), as well as myocardial fibrosis. The purpose of this study is to examine the relationship between myocardial perfusion reserve (MPR) and diffuse myocardial fibrosis in patients with HFpEF using CMR. A single center study was performed in 19 patients with clinical HFpEF and 15 healthy control subjects who underwent quantitative first-pass perfusion imaging to calculate global MPR.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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