Interplay between epigenetic abnormalities and deregulated expression of microRNAs in cancer

Publication date: Available online 8 February 2019Source: Seminars in Cancer BiologyAuthor(s): Ammad Ahmad Farooqi, Enrique Fuentes-Mattei, Sundas Fayyaz, Priyank Raj, Matthew Goblirsch, Palmiro Poltronieri, George A. CalinAbstractEpigenetic abnormalities and aberrant expression of non-coding RNAs are two emerging features of cancer cells, both of which are responsible for deregulated gene expression. In this review, we describe the interplay between the two. Specific themes include epigenetic silencing of tumor suppressor miRNAs, epigenetic activation of oncogenic miRNAs, epigenetic aberrations caused by miRNAs, and naturally occurring compounds which modulate miRNA expression through epigenetic mechanisms.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research