A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease.

A longitudinal study of polysomnographic variables in patients with mild cognitive impairment converting to Alzheimer's disease. J Sleep Res. 2019 Feb 06;:e12821 Authors: Carnicelli L, Maestri M, Di Coscio E, Tognoni G, Fabbrini M, Schirru A, Giorgi FS, Siciliano G, Bonuccelli U, Bonanni E Abstract The main condition at increased risk of dementia is considered to be mild cognitive impairment. Mild cognitive impairment has been defined as a transitional state between normal aging and dementia, of which it may represent a prodrome. The aim of our study was to evaluate whether sleep variables (both conventional and microstructural ones) in subjects with mild cognitive impairment correlate with conversion to dementia. Nineteen subjects with amnestic mild cognitive impairment (mean age 68.5 ± 7.0 years) and 11 cognitively intact healthy elderly individuals (mean age 69.2 ± 12.6 years) underwent ambulatory polysomnography for the evaluation of nocturnal sleep architecture and cyclic alternating pattern parameters. Amnestic mild cognitive impairment subjects were clinically and cognitively re-evaluated after 2 years, during routine follow-up, and further classified as amnestic mild cognitive impairment converters (that is, patients developing Alzheimer's disease, N = 11) and amnestic mild cognitive impairment non-converters. Compared with healthy elderly individuals, amnestic mild cognitive impairment showed disrupted sl...
Source: Journal of Sleep Research - Category: Sleep Medicine Authors: Tags: J Sleep Res Source Type: research