Identical twins light the way for new genetic cause of arthritis

(VIB (the Flanders Institute for Biotechnology)) Identical twin toddlers who presented with severe arthritis helped scientists to identify the first gene mutation that can single-handedly cause a juvenile form of this inflammatory joint disease. By investigating the DNA of individual blood cells of both children and then modelling the genetic defect in a mouse model, the research team led by Adrian Liston (VIB-KU Leuven) was able to unravel the disease mechanism.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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CONCLUSION: Tofacitinib did not require dose modification or restrictions for age, body weight, sex, race, ethnicity, or baseline disease severity in patients with active PsA based on the magnitude of exposure relative to a reference patient. Dosing adjustments for renal impairment were derived from a separate phase 1 study.
. PMID: 31319908 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Conclusion. EA on ST36 and GB39 acupoints can effectively inhibit synovial angiogenesis in the AA rat model via downregulating HIF-1α/VEGF expression. PMID: 31316573 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
CONCLUSIONS This study suggested that the TT genotype and T allele in rs17221959 decreased RA risk. Smoking could decrease the protective effect of TT. PMID: 31316048 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Knee pain due to arthritis or injury is the second most common cause of chronic pain in the United States. Osteoarthritis affects more than 30 million adults in the United States. And the rate of anterior cruciate ligament (ACL) tears among children and teens has been increasing about 2.3% per year for the past two decades, according to a new study. The specific cause of a patient’s knee pain has always been difficult to determine because diagnostic tools such as x-ray or MRI only image the joint in a static standing or lying down position, not in motion when the patient is feeling pain. â€...
Source: MDDI - Category: Medical Devices Authors: Tags: Orthopedics Source Type: news
Authors: Dalal A PMID: 31315345 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Jagdish RK, Shailly, Bhatnagar MK PMID: 31315331 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
AbstractObjectivesTo develop and evaluate an illustrated, stand-alone, interactive evidence-based shared decision making (SDM) aid for JIA children; its ability to produce positive perceived involvement of JIA patients in their own management and its impact on their adherence to therapy, school absenteeism and treatment outcomes.MethodsThe SDM aid was developed to offer information about the disease, risks and benefits of treatment. A multidisciplinary team defined SDM criteria based on international standards (IPDAS). Eight categories emerged as highly important for SDM. Each category was supported by simple illustrations...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conclusions: These findings demonstrate that: 1) TNF-Tg mice display a restrictive pathology, and 2) in vivo µCT is a valid outcome measure to infer changes in pulmonary mechanical and functional parameters. PMID: 31318607 [PubMed - as supplied by publisher]
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
This study is based on data from IMS® Diagnosis Monitor and included patients who had received a biological drug in dermatology practices due to psoriasis (PSO), gastroenterology practices due to Crohn's disease (CD) or ulcerative colitis (UC), or rheumatology practices due to rheumatoid arthritis (RA) between April 2015 and December 2018. We analyzed 1,748,948 CD/UC-related prescriptions, 3,968,879 RA-related prescriptions, and 7,321,496 PSO-related prescriptions. Of these, 343,263 (19.6%) prescriptions for IBD, 92,343 (16.2%) prescriptions for RA, and 169,573 (6.9%) prescriptions for PSO were for biologicals. The pro...
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 18 July 2019Source: Arthroscopy TechniquesAuthor(s): G. Klaud MillerAbstractThe barrel vault tibial osteotomy performed for knee varus osteoarthritis avoids the complications of the opening wedge osteotomy and minimizes the potential complications of the lateral closing wedge osteotomy. It allows correction of large varus deformities in knee medial compartment osteoarthritis.
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
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