High frequency stimulation of the subthalamic nucleus: linking mood and motor effects at the level of the basal ganglia and 5-HT system

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a neurosurgical procedure commonly used for the management of severe movement disability in advanced Parkinson ’s disease (PD), but some patients experience debilitating psychiatric effects that have an uknown neural origin. Here we use animal models to uncover effects of DBS of the STN on the lateral habenula nucleus (LHb), a fast emerging controller of motivational and emotive behaviours, and a major sou rce of input to 5-HT neurons in the dorsal raphe nucleus (DRN).

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Y. Temel Source Type: research