Towards multi-focal orhcestrated neuromoduation to enhance recovery

Motor stroke, although defined by its single focal lesion in the motor system, is a network disorder with significant functional and structural changes within the large bilateral motor network involved in the implementation of movements (Koch&Hummel, 2017). During the recovery process there is also significant reorganization within the motor cortical network depending on the site and size of the lesions and the phase of the recovery process from the acute to the chronic stage. In the present presentation, structural and functional changes relevant for the process of functional reorganization and recovery will be discussed with the focus to determine novel targets for neuromodulation (such as premotor cortex or cerebellum) and leverage these factors for phenotyping of patients towards patient-tailored interventions.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: F. Hummel Source Type: research