Static and dynamic postural control deficits in aging fragile X mental retardation 1 ( FMR1 ) gene premutation carriers

ConclusionOur findings indicate that agingFMR1 premutation carriers show static and dynamic postural control deficits relative to healthy controls implicating degenerative processes of spinocerebellar and cerebellar-brainstem circuits that may be independent of or precede the onset of FXTAS. Our finding that FXTAS+ and FXTAS − premutation carriers differed on their level of intentional AP sway suggests that neural mechanisms of dynamic postural control may be differentially impacted in patients with FXTAS, and its measurement may be useful for rapidly and precisely identifying disease presence and onset.

Source: Journal of Neurodevelopmental Disorders - January 21, 2019 Category: Neurology Source Type: research