Cancers, Vol. 11, Pages 125: Influence of Vitamin D in Advanced Non-Small Cell Lung Cancer Patients Treated with Nivolumab
Cancers, Vol. 11, Pages 125: Influence of Vitamin D in Advanced Non-Small Cell Lung Cancer Patients Treated with Nivolumab
Cancers doi: 10.3390/cancers11010125
Authors:
Jessica Cusato
Carlo Genova
Cristina Tomasello
Paolo Carrega
Selene Ottonello
Gabriella Pietra
Maria Mingari
Irene Cossu
Erika Rijavec
Anna Leggieri
Giovanni Perri
Maria Bello
Simona Coco
Simona Boccardo
Guido Ferlazzo
Francesco Grossi
Antonio D’Avolio
Nivolumab is one of the most commonly used monoclonal antibodies for advanced non-small cell lung cancer treatment, to the extent that the presence of its anti-antibody is considered a negative prognostic factor. Vitamin D (VD) modulates expression of the genes involved in drug metabolism and elimination. Immune system regulation and immunodeficiency is frequent in non-small cell lung cancer patients. To date, no data have been reported about the relationship between nivolumab and VD. The aim of this study was to quantify plasma 25-hydroxyVD (25-VD) and 1,25-VD, nivolumab, and its anti-antibody before starting treatment (baseline) and at 15, 45 and 60 days of therapy. VD-pathway-associated gene single nucleotide polymorphisms (SNPs) were also evaluated. Molecules were quantified through enzyme-linked immunosorbent assay, and SNPs through real-time PCR. Forty-five patients were enrolled. Median nivolumab concentrations were 12.5 ug/mL, 22.3 ug/mL and 27.1 ug/mL at 15, 45 and 60 days respectively. No anti-nivolumab antibod...
Source: Cancers - Category: Cancer & Oncology Authors: Jessica Cusato Carlo Genova Cristina Tomasello Paolo Carrega Selene Ottonello Gabriella Pietra Maria Mingari Irene Cossu Erika Rijavec Anna Leggieri Giovanni Perri Maria Bello Simona Coco Simona Boccardo Guido Ferlazzo Francesco Grossi Antonio D ’Avolio Tags: Article Source Type: research
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