Ginger: A novel strategy to battle cancer through modulating cell signalling pathways.

Ginger: A novel strategy to battle cancer through modulating cell signalling pathways.
Curr Pharm Biotechnol. 2019 Jan 19;:
Authors: Almatroudi A, Alsahli MA, Alrumaihi F, Allemailem KS, Rahmani AH
Abstract
Numerous studies have been performed in understanding the development of cancer. Though, the mechanism of action of genes in the development of cancer remains to be explained. The current mode of treatment of cancer shows adverse effect on normal cells and also alter the cell signalling pathways. However, ginger and their active compound has fascinated research based on animal model and laboratories during past decade due to its potentiality in killing of cancer cells. Ginger is a mixture of various compound including gingerol, paradol, zingiberene and shogaol and such compound are main player in the diseases management. Most of health promoting effects of ginger and its active compound can be attributed to its antioxidant and anti-tumour activity. Besides, active compound of ginger has proven their role in cancer management through its modulatory effect on tumour suppressor genes, cell cycle, apoptosis, transcription factors, angiogenesis and growth factor. In this review, role of ginger and their active compound in the inhibition of cancer growth through modulating cell signalling pathways will be reviewed and discussed.
PMID: 30659535 [PubMed - as supplied by publisher]

Source: Current Pharmaceutical Biotechnology - January 19, 2019 Category: Biotechnology Authors: Almatroudi A, Alsahli MA, Alrumaihi F, Allemailem KS, Rahmani AH Tags: Curr Pharm Biotechnol Source Type: research