Re: Sebastian Berg, Alexander P. Cole, Marieke J. Krimphove, et al. Comparative Effectiveness of Radical Prostatectomy Versus External Beam Radiation Therapy Plus Brachytherapy in Patients with High-risk Localized Prostate Cancer. Eur Urol. In press. Comparing Apples to Oranges: A Self-fulfilling Prophecy?

Publication date: Available online 19 January 2019Source: European UrologyAuthor(s): Amar U. Kishan, William A. Hall, Daniel E. Spratt
Source: European Urology - Category: Urology & Nephrology Source Type: research

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AbstractProstate cancer is the second leading cause of death from cancer, behind lung cancer, for men in the U. S, with nearly 30,000 deaths per year. A key problem is the difficulty in distinguishing, after biopsy, between significant cancers that should be treated immediately and clinically insignificant tumors that should be monitored by active surveillance. Prostate cancer has been over-treated; a recent European randomized screening trial shows overtreatment rates of 40%. Overtreatment of insignificant tumors reduces quality of life, while delayed treatment of significant cancers increases the incidence of metastatic ...
Source: Health Care Management Science - Category: Hospital Management Source Type: research
(European Association of Urology) For the first time, scientists have identified compounds found in coffee which may inhibit the growth of prostate cancer. This is a pilot study, carried out on drug-resistant cancer cells in cell culture and in a mouse model; it has not yet been tested in humans. This work is presented at the European Association of Urology congress in Barcelona, after publication in the peer-reviewed journal The Prostate* (this press release contains additional material).
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Publication date: Available online 15 March 2019Source: SteroidsAuthor(s): Qiangqiang Hou, Conghui He, Kejing Lao, Guoshun Luo, Qidong You, Hua XiangAbstractBoth AR and CYP17 are important targets for blocking androgen signaling, and it has been accepted that multifunctional drugs have a low risk of drug resistance in the treatment of cancer. Thus, herein a series of steroidal imidazoles were designed, synthesized and evaluated as dual AR/CYP17 ligands. Several compounds displayed good biological profiles in both enzymatic and cellular assays. SAR studies showed that introducing oximino at the C-3 position of steriodal sca...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
(MedPage Today) -- This week's topics also include wearable technologies and surgery recovery, and a patient reportedly cured of HIV
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
Publication date: Available online 15 March 2019Source: Environmental Toxicology and PharmacologyAuthor(s): Ying Xiang, Liang Zhang, Yu Huang, Junjun Ling, Wenlei ZhuoAbstractIncreasing evidence showed that Cadmium (Cd) can accumulate in the body and damage cells, resulting in cancerigenesis of prostate with complex mechanisms. In the present study, we aimed to explore the possible key genes, pathways and therapeutic drugs using bioinformatics methods. Microarray-based data were retrieved and analyzed to screen differentially expressed genes (DEGs) between Cd-treated prostate cells and controls. Then, functions of the DEGs...
Source: Environmental Toxicology and Pharmacology - Category: Environmental Health Source Type: research
We present the case of a 71 year old man with a history of adenocarcinoma of the prostate who developed cancer associated retinopathy concomitant with small cell transformation. This represents an unusual paraneoplastic syndrome that may be progressive and irreversible, requiring prompt diagnosis and treatment to preserve visual function and guide further oncological care.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 March 2019Source: European UrologyAuthor(s): Karen E. Knudsen, Felix Y. Feng
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conclusion Combined impact loading and resistance exercise attenuates bone loss at the spine and enhances overall musculoskeletal function in PCa patients undergoing ADT.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Publication date: Available online 15 March 2019Source: European Journal of RadiologyAuthor(s): Xiangde Min, Min Li, Di Dong, Zhaoyan Feng, Peipei Zhang, Zan Ke, Huijuan You, Fangfang Han, He Ma, Jie Tian, Liang WangAbstractPurposeTo evaluate the performance of a multi-parametric MRI (mp-MRI)-based radiomics signature for discriminating between clinically significant prostate cancer (csPCa) and insignificant PCa (ciPCa).Materials and methodsTwo hundred and eighty patients with pathology-proven PCa were enrolled and were randomly divided into training and test cohorts. Eight hundred and nineteen radiomics features were extr...
Source: European Journal of Radiology - Category: Radiology Source Type: research
(MedPage Today) -- Validation study confirms assist in decision-making
Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
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