Conotoxin {kappa}M-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels [Neuroscience]

The vast complexity of native heteromeric K+ channels is largely unexplored. Defining the composition and subunit arrangement of individual subunits in native heteromeric K+ channels and establishing their physiological roles is experimentally challenging. Here we systematically explored this “zone of ignorance” in molecular neuroscience. Venom components, such as peptide toxins,...

Source: Proceedings of the National Academy of Sciences - January 15, 2019 Category: Science Authors: Sonke Cordeiro, Rocio K. Finol–Urdaneta, David Kopfer, Anna Markushina, Jie Song, Robert J. French, Woȷciech Kopec, Bert L. de Groot, Mario J. Giacobassi, Lee S. Leavitt, Shrinivasan Raghuraman, Russell W. Teichert, Baldomero M. Olivera, Hein Tags: Biological Sciences Source Type: research