Molecular alterations in primary cutaneous CD30 lymphoproliferative disorders.

Molecular alterations in primary cutaneous CD30 lymphoproliferative disorders.
Haematologica. 2019 Jan 10;:
Authors: Prieto-Torres L, Rodriguez-Pinilla SM, Onaindia A, Ara M, Requena L, Piris MA
Abstract
Primary cutaneous CD30-positive T-cell lymphoproliferative disorders (LPDs) are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases, lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (pcALCL). Molecular studies of pcALCL reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30+ LPD, and their potential as therapeutic targets.
PMID: 30630983 [PubMed - as supplied by publisher]

Source: Haematologica - January 10, 2019 Category: Hematology Authors: Prieto-Torres L, Rodriguez-Pinilla SM, Onaindia A, Ara M, Requena L, Piris MA Tags: Haematologica Source Type: research