Structure-Activity Relationships of Cytotoxic Lactones as Inhibitors and Mechanisms of Action.

CONCLUSION: Likely action mechanisms for lactones are argued with a diversity of functional groups in the lactone annulus, including artemisinin with its uncommon macrocycle characteristic, 1,2,4 trioxane cycle (pharmacophoric peroxide linkage -O1-O2- in endoperoxide ring), which results the foundation for its sole antimalarial potency. PMID: 30621564 [PubMed - as supplied by publisher]
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research