Unusual Focal Muscle FDG Activity Related to Altered Biomechanics

A 20 year old man suffered severe right knee pain, especially when his right foot touched ground. The MRI findings suggested periosteal osteosarcoma, which led to a staging FDG PET/CT. The images showed not only a hypermetabolic right knee lesion but also focally elevated activity in select muscles, which was attributed to altered biomechanics. The resected lesion was pathologically proven as periosteal chondrosarcoma instead of periosteal osteosarcoma. In a follow-up period of 4 years after the surgery, there was no recurrent disease, nor any abnormality in the muscles which showed focal FDG activity on the initial FDG PET/CT.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research

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Discussion: Until now, positive effect of LIPUS have been reported on osteonecrosis of knee, hip joint and jaw bone. However, there have been, to our knowledge, no report on applying LIPUS for these difficult conditions. LIPUS therapy seems beneficial for pain relief and bone regeneration for massive osteonecrosis after CIR. Accepted June 13, 2019 Copyright © 2019 Wolters Kluwer Health, Inc. All rights reserved.
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Supplement: PDF Only Source Type: research
Conclusions: The proposed nomogram is a reliable and robust tool for accurate prognostic prediction in patients with extremity soft tissue LMS. Introduction Soft tissue leiomyosarcoma (LMS) is an aggressive sarcoma, which originates from smooth muscle cells (1). Soft tissue LMS accounts for about 5–10% of all soft tissue sarcomas (2). It occurs in different sites, including the retroperitoneum, intraabdominal sites, and extremities (3). Extremity LMS comprised about 10–15% of extremity sarcomas, with a preference for the lower limb (4–6). Extremity LMS tends to have a better prognosis than uterine...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSION: Surgical treatment of primary malignant tumors of the proximal fibula is problematic. In appropriate indications, Malawer type 1 resection should be the treatment of choice due to lower local recurrence rates and higher MSTS scores. PMID: 30885105 [PubMed - in process]
Source: Eklem Hastaliklari ve Cerrahisi - Category: Orthopaedics Tags: Eklem Hastalik Cerrahisi Source Type: research
AbstractWe herein report a rare case of mesenchymal hamartoma of the chest wall in a 10-year-old girl. She complained of chest pain and was diagnosed with a large chest wall tumor originating from the left fourth rib. Malignancy such as osteosarcoma or chondrosarcoma could not be ruled out with imaging studies. Therefore, we performed a core needle biopsy assisted by thoracoscopy, which revealed no malignancy. Therefore, extended resection with chest wall reconstruction was unnecessary, and thoracoscopy-assisted tumor excision with only the removal of the involved fourth rib was performed without chest wall reconstruction....
Source: Skeletal Radiology - Category: Radiology Source Type: research
DiscussionWidening of the PDL space is an important finding associated with malignant disease and may occur with sarcomas and non-Hodgkin lymphoma. 2,5 Widening of the PDL space was identified in nearly half the osteosarcoma cases reported by Fernandes et al.2 The combination of PDL widening, sclerotic bone pattern with bone formation, and higher incidence of osteosarcoma compared with chondrosarcoma can be used to identify osteosarcoma cases radiographically.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Authors: Hardes J, Gosheger G, Budny T Abstract Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma. Osteosarcomas and Ewing sarcomas occur predominantly...
Source: Zeitschrift fur Orthopadie und Unfallchirurgie - Category: Orthopaedics Tags: Z Orthop Unfall Source Type: research
Dr. Vincent Ng is an orthopaedic oncologist with the University of Maryland Greenebaum Comprehensive Cancer Center and an Assistant Professor or Orthopaedics with the University of Maryland School of Medicine.  Dr. Ng specializes in treating bone cancer and soft tissue sarcoma.  Below he answers common questions about orthopaedic oncology. What is an orthopaedic oncologist? How do they differ from surgical oncologists? “An orthopaedic oncologist specializes in bone and soft tissue tumors.  I treat any adult or pediatric patient with any bone or soft tissue tumor/lesion/mass, whether benign or malignan...
Source: Life in a Medical Center - Category: Universities & Medical Training Authors: Tags: Cancer Doctors bone cancer oncology orthopedics Source Type: blogs
Conclusions Our findings suggest that when low back pain and leg pain are refractory to conservative treatment, further radiological examination should be conducted. J. Med. Invest. 63: 274-277, August, 2016. PMID: 27644571 [PubMed - as supplied by publisher]
Source: Journal of Medical Investigation - Category: Journals (General) Tags: J Med Invest Source Type: research
CONCLUSION: TES is a paradigmatic operation, in which the concept of radical resection provides functional effectiveness and improves survival in selected patients suffering from spinal tumours. Our preliminary experience allows us to highlight some specific and relevant features, especially those favouring a simpler and safer operation. PMID: 27639666 [PubMed - as supplied by publisher]
Source: Neurocirugia - Category: Neurosurgery Authors: Tags: Neurocirugia (Astur) Source Type: research
We report two cases of giant cell tumor arising from the rib and their F-18 FDG PET/CT findings. The two patients complained of chest wall pain, and large lobulated soft tissue masses with intense FDG uptake were seen on F-18 FDG PET/CT. A malignant tumor such as osteosarcoma or chondrosarcoma was suspected due to the large size of the mass, bony destruction, and intense FDG uptake. En bloc resection was performed and final pathologic results revealed giant cell tumor of the rib. Giant cell tumor of the rib is very rare, and larger lesions with high FDG uptake can be misdiagnosed as an intrathoracic malignancy arising from...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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