The clinical and pathological features of adefovir dipivoxil-related renal impairment 
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CONCLUSION: Nephrotoxicity developed in patients undergoing long-term ADV treatment and was partially reversible after drug cessation. Tubulointerstitial lesions and heteromorphic mitochondria were the predominant pathological changes. Patients with ADV-induced renal impairment should replace ADV with other antiviral agents other than tenofovir.
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PMID: 30614440 [PubMed - as supplied by publisher]

Source: Clinical Nephrology - January 7, 2019 Category: Urology & Nephrology Authors: Lv Y, Li X, Liang S, Liang D, Xu F, Zhu X, Zeng C Tags: Clin Nephrol Source Type: research