Systemic administration of serotonin exacerbates abdominal pain and colitis via interaction with the endocannabinoid system.

CONCLUSIONS: Our study shows a link between 5-HT and endocannabinoid signaling pathways in IBD. Thus, pharmacological blockade of 5-HT signaling or supplementation with endocannabinoids in the gut might be of benefit in severe cases of abdominal pain in IBD.
PMID: 30611738 [PubMed - as supplied by publisher]

Source: Biochemical Pharmacology - January 3, 2019 Category: Drugs & Pharmacology Authors: Salaga M, Binienda A, Piscitelli F, Mokrowiecka A, I Cygankiewicz A, Verde R, Malecka-Panas E, Kordek R, Krajewska WM, Di Marzo V, Fichna J Tags: Biochem Pharmacol Source Type: research