10‐Year Results of Therapeutic Ratio by Intensity‐Modulated Radiotherapy Versus Two‐Dimensional Radiotherapy in Patients with Nasopharyngeal Carcinoma

AbstractBackground.The purpose of this study was to verify 10‐year results of survival and late toxicities and assess the ultimate therapeutic ratio of intensity‐modulated radiotherapy (IMRT) versus two‐dimensional radiotherapy (2DRT) in patients with nasopharyngeal carcinoma (NPC).Materials and Methods.We retrospectively reviewed the data from 1,276 patients with nonmetastatic NPC who received IMRT or 2DRT from January 2003 to December 2006.Results.Of the 1,276 patients, 512 were treated with IMRT and 764 with 2DRT. Median follow‐up was 115 months. At 10 years, the IMRT group demonstrated significantly better results than the 2DRT group in local failure‐free survival (L‐FFS; 90% vs. 84%; hazard ratio [HR], 0.57, 95% confidence interval [CI], 0.40–0.81; p = .001), failure‐free survival (FFS; 69% vs. 58%; HR, 0.69, 95% CI, 0.57–0.83; p 

Source: The Oncologist - January 8, 2019 Category: Cancer & Oncology Authors: Lei Chen, Yuan Zhang, Shu-Zhen Lai, Wen-Fei Li, Wei-Han Hu, Rui Sun, Li-Zhi Liu, Fan Zhang, Hao Peng, Xiao-Jing Du, Ai-Hua Lin, Ying Sun, Jun Ma Tags: Head and Neck Cancers Source Type: research