Over-the-counter painkillers like aspirin and ibuprofen may make C.difficile more aggressive  

A study by Vanderbilt University found just 20 per cent of mice treated with the non-steroidal anti-inflammatory drug indomethacin before being exposed to C.difficile survived the infection.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Publication date: Available online 12 June 2019Source: Journal of Hospital InfectionAuthor(s): Stefanie Gemein, Jürgen Gebel, Bärbel Christiansen, Heike Martiny, Lutz Vossebein, Florian H.H. Brill, Maja Decius, Maren Eggers, Torsten Koburger-Janssen, Maren Meckel, Sebastian Werner, Birgit Hunsinger, Thomas Selhorst, Günter Kampf, Martin ExnerSummarySporicidal surface disinfection is recommended to control transmission of Clostridium difficile in healthcare facilities. EN 17126 provides a method to determine the sporicidal activity in suspension and has been approved as a European standard. In addition, a spo...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
The agency said two patients received donated stool that had not been screened for drug-resistant germs, leading it to halt clinical trials until researchers prove proper testing procedures are in place.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Drug Resistance (Microbial) Antibiotics fecal transplant Clostridium Difficile (Bacterium) E Coli (Bacteria) Food and Drug Administration Digestive Tract your-feed-healthcare Source Type: news
Newly revealed links between inflammation, obesity and cardiometabolic syndrome have created opportunities to try previously unexplored therapeutic modalities in these common and life-risking disorders. One potential modulator of these complex disorders is the gut microbiome, which was described in recent years to be altered in patients suffering from features of cardiometabolic syndrome and to transmit cardiometabolic phenotypes upon transfer into germ-free mice. As a result, there is great interest in developing new modalities targeting the altered commensal bacteria as a means of treatment for cardiometabolic syndrome. ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 12 June 2019Source: Journal of Hospital InfectionAuthor(s): Stefanie Gemein, Jürgen Gebel, Katrin Steinhauer, Bärbel Christiansen, Heike Martiny, Bernhard Meyer, Christiane Ostermeyer, Hans-Joachim Rödger, Lutz Vossebein, Lars Paßvogel, Florian H.H. Brill, Maja Decius, Maren Eggers, Torsten Koburger-Janssen, Maren Meckel, Heike Vogelsang, Sebastian Werner, Birgit Hunsinger, Thomas Selhorst, Günter KampfSummarySporicidal surface disinfection is recommended to control transmission of Clostridium difficile in healthcare facilities. EN 17126 provides a method to dete...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionUse of PPIs during CDI treatment in elderly patients is associated with decreased 180-day mortality. Although use of PPIs has been associated with an increased risk of CDI, it appears to be protective against mortality when used during the treatment phase.
Source: Gut Pathogens - Category: Microbiology Source Type: research
Objectives: To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery. Summary Background Data: Meta-analyses have demonstrated that MBP does not impact upon postoperative morbidity or mortality, and as such it should not be prescribed routinely. However, recent evidence from large retrospective cohort and database studies has suggested that there may be a role for combined OAB and MBP, or OAB alone in the prevention of surgical site infection (SSI). Methods: A meta-analysis of randomized controlled trials and cohort studi...
Source: Annals of Surgery - Category: Surgery Tags: META-ANALYSES Source Type: research
ConclusionsOur study showed that PPI use was associated with an increased risk of developing CDI and the risk of CDI was dose dependent. Therefore, PPIs should only be used at proper doses and only for the necessary indications to avoid CDI risk.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
The objective of this study was to provide data-driven estimates of CDI timelines of diagnosis, isolation, and treatment in a hospital setting.MethodsWe obtained data for all CDI inpatients with symptoms onset occurring between January 1, 2013, and December 30, 2017, from St Joseph's Healthcare in Hamilton, Canada. We analyzed full empirical distributions of timelines associated with the diagnosis, isolation, and treatment of CDI.ResultsA total of 683 inpatients with CDI symptoms were recorded, of which 243 cases were identified as health care–associated infection (HAI). The mean time intervals between the onset of C...
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Publication date: May 2019Source: European Urology Supplements, Volume 18, Issue 2Author(s): S. Leafu Popa, G. Predoiu, R.A. Danau, A. Obada, B. Braticevici, V. Jinga
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
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