Medicinal potential of Panax ginseng and its ginsenosides in atopic dermatitis treatment

Publication date: Available online 7 January 2019Source: Journal of Ginseng ResearchAuthor(s): Laura Rojas Lorz, Mi-Yeon Kim, Jae Youl ChoAbstractAtopic dermatitis (AD) is a chronic and relapsing inflammatory disease that affects 1%-20% of people worldwide. Despite affecting many people, AD current treatments such as corticosteroids and calcineurin inhibitors, have not only harmful secondary effects but are also often ineffective. Therefore, natural non-toxic compounds are on high demand for developing new effective AD treatments. Panax ginseng Meyer, has been used traditionally for its promising healing and restorative properties to treat many diseases including skin disorders, reason why in this review we want to explore the research done with AD and P. ginseng as well as determining its potential for new drug development. Previous researches have shown that P. ginseng has positive effects in AD patients such as lower EASY, TEWL, IgE levels and better quality of sleep. In vivo animal models as well, have shown positive results to P. ginseng and derived ginsenosides, such as the decrease of TEWL, IgE levels in serum, allergy related cytokines and downregulation of NF-κB, MAPK and Ikaros pathways. All of this previous data suggesting that P. ginseng and its derived ginsenosides are undoubtedly a non-toxic effective option to treat AD.
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research