Cambridge drug developer Tiburio launches, targeting pituitary tumors with $31M

A Cambridge startup hoping to develop the first drug treatments to shrink dangerous tumors on the brain's pituitary gland launched Thursday with $31 million in funding. Tiburio Therapeutics Inc. was spun out of Cambridge orphan disease accelerator Cydan this week with the Series A funding from New Enterprise Associates, Longitude Capital and Alexandria Real Estate Equities Inc.'s (NYSE: ARE) venture arm, Alexandria Venture Investments. Ibsen, which moved its U.S. headquarters to Massachusetts last…
Source: Health Care:Biotechnology headlines - Category: Biotechnology Source Type: news

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Discussion of the Evolutionary Genetics of Aging Thymic Involution Contributes to Immunosenescence and Inflammaging The Potential for Exosome Therapies to Treat Sarcopenia Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice The Aging Retina, a Mirror of the Aging Brain Evidence for Loss of Capillary Density to be Important in Heart Disease Aspects of Immune System Aging Proceed More Rapidly in Men Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation Transplantation of Senescent Cells is an ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(Houston Methodist) Houston Methodist neurosurgeons are looking at a new way to classify pituitary tumors that could lead to more precise and accurate diagnosing for patients in the future. These tests also could have potential for better diagnoses in other brain tumors. The findings, published Jan. 28 in Scientific Reports, describe a new way to study the blood of pituitary adenoma patients to determine tumor type and whether they might respond to medical treatment rather than surgery.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
Rationale: Pituitary apoplexy (PA) and posterior reversible encephalopathy syndrome (PRES) are rare neurologic diseases that show acute neuro-ophthalmologic symptoms such as headache, decreased visual acuity, and altered consciousness. These diseases are rarely found in patients with end-stage renal disease (ESRD) on hemodialysis, and simultaneous occurrence of these 2 diseases has not been reported. Patient concerns: The patient was a 75-year-old man with a history of hypertension, diabetes mellitus, and non-functioning pituitary macroadenoma. He had been receiving hemodialysis for ESRD for 3 months before his presen...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: Available online 10 December 2019Source: Artificial Intelligence in MedicineAuthor(s): Sarah Ali Abdelaziz Ismael, Ammar Mohammed, Hesham HefnyAbstractCancer is the second leading cause of death after cardiovascular diseases. Out of all types of cancer, brain cancer has the lowest survival rate. Brain tumors can have different types depending on their shape, texture, and location. Proper diagnosis of the tumor type enables the doctor to make the correct treatment choice and help save the patient's life. There is a high need in the Artificial Intelligence field for a Computer Assisted Diagnosis (CAD) syste...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
__________ Just a heads-up about a great event later this week in Dublin, Ireland, for those working on virtual and augmented reality and healthcare innovation. When: Thu Dec 5, 2019 8:00 am — Fri Dec 6, 2019 5:00 pm. Where: Davenport Hotel Featured sessions include: Day 1 – Thursday, December 5th, 2019 9:00am‑9:30am Introductions, Welcome and Setting The Stage Robert Fine, Executive Director, International Virtual Reality and Healthcare Association (IVRHA) 9:30am-10:30am Keynote Presentation:  Virtual Reality and Healthcare: The Past, The Present and The Future Dr. Walter Gree...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology augmented reality Dublin healthcare healthcare innovation virtual-reality Source Type: blogs
Publication date: March 2020Source: Biomedical Signal Processing and Control, Volume 57Author(s): Navid Ghassemi, Afshin Shoeibi, Modjtaba RouhaniAbstractIn this paper, a new deep learning method for tumor classification in MR images is presented. A deep neural network is first pre-trained as a discriminator in a generative adversarial network (GAN) on different datasets of MR images to extract robust features and to learn the structure of MR images in its convolutional layers. Then the fully connected layers are replaced and the whole deep network is trained as a classifier to distinguish three tumor classes. The deep neu...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
CONCLUSION: A highly focused imaging protocol is important for the diagnosis of sellar lesions such as pituitary tumors. The current favored modality is contrast-enhanced MRI, preferably with dynamic contrast-enhanced T1-weighted sequences. Early detection of the lesions and identification of the precise anatomical location are of great importance for diagnosis and therapy. PMID: 31321467 [PubMed - as supplied by publisher]
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Derin Gebhardt, 37, from Roundup, Montana, was diagnosed in May 2017 with a pituitary tumor, which was causing a decrease in normal levels of sex hormones and behind his infertility.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ConclusionWe highlighted how pituitary apoplexy may mimic the clinical findings of an infectious meningoencephalitis, learning points on how clinical assessment can aid earlier diagnosis and the importance of considering this differential diagnosis, particularly with the associated morbidity and mortality.
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
CONCLUSION: Neurological signs recorded in DPM-affected dogs include not only the typical forebrain signs but also gait disturbances and hyperesthesia. Neurological signs are positively associated with increased P:B ratio and MRI signs of brain compression. PMID: 31112462 [PubMed - as supplied by publisher]
Source: Veterinary Quarterly - Category: Veterinary Research Tags: Vet Q Source Type: research
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