dFunctional connectivity between Hippocampus and Lateral septum is affected in very young Alzheimer’s transgenic mouse model

Publication date: Available online 30 December 2018Source: NeuroscienceAuthor(s): Siddhartha Mondragón-Rodríguez, Ning Gu, Caroline Fasano, Fernando Peña-Ortega, Sylvain WilliamsAbstractAlzheimer’s disease (AD) is characterized by the accumulation of amyloid-β and tau proteins, which are believed to lead to neural damage that translates into brain dysfunction and cognitive deficits. Brain dysfunction can be evaluated by measuring single neuron activity (spikes), global neural activity (local field potentials, LFPs) and the interaction between them. Considering that the dynamic interactions between the hippocampal pyramidal cells and lateral septum are important for proper structure function, we used the complete septo-hippocampal preparation from 30-day-old controls and J20-AD transgenic mice to record changes in spiking activity from the lateral septum and its relationship with LFP activity from the CA1 area. The cross-correlation analysis revealed that young J20 transgenic mice exhibit a significant reduction in coupling between lateral septum single cell activity and neural network activity from the hippocampal CA1. Consistently, phase-lock analysis between lateral septum single cell activity and CA1 neural network activity showed lower values in J20 transgenic mice. Similarly, the LFP- LFP coherence between CA1 and septum in the theta range showed lower values in J20 animals. Importantly, alterations were found before any detectable signs of cognitive deficits. Our ...
Source: Neuroscience - Category: Neuroscience Source Type: research