Development and Evaluation of Nanoemulsion and Microsuspension Formulations of Curcuminoids for Lung Delivery with a Novel Approach to Understanding the Aerosol Performance of Nanoparticles

Publication date: Available online 28 December 2018Source: International Journal of PharmaceuticsAuthor(s): Yuosef. Al ayoub, R.C. Gopalan, M. Najafzadeh, M. Amin, D. Anderson, A. Paradkar, K.H. AssiAbstractExtensive research has demonstrated the potential effectiveness of curcumin against various diseases, including asthma and cancers. However, few studies have used liquid-based vehicles in the preparation of curcumin formulations. Therefore, the current study proposed the use of nanoemulsion and microsuspension formulations to prepare nebulised curcuminoid for lung delivery. Furthermore, this work expressed a new approach to understanding the aerosol performance of nanoparticles compared to microsuspension formulations. The genotoxicity of the formulations was also assessed. Curcuminoid nanoemulsion formulations were prepared in three concentrations (100, 250 and 500 µg/ml) using limonene and oleic acid as oil phases, while microsuspension solutions were prepared by suspending curcuminoid particles in isotonic solution (saline solution) of 0.02% Tween 80. The average fine particle fraction (FPF) and mass median aerodynamic diameter (MMAD) of the nebulised microsuspension formulations ranged from 26% and 7.1 µm to 40% and 5.7 µm, for 1000 µg/ml and 100 µg/ml respectively. In a comparison of the low and high drug concentrations of the nebulised nanoemulsion, the average FPF and MMAD of the nebulised nanoemulsion formulations prepared with limonene oil ranged from 50% and...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research