Stress induced cardiomyopathy complicated by cardiogenic shock: A non-survivor case

We present a case of female patient presented with cardiogenic shock after rupture globe operation, patient presented on mega doses of vasopressors and inotropes, peripheral percutaneous VA ECMO was instituted, IABP was put to deload leftventricle, 2 days later patient was shifted to VAV ECMO. After 4 days of ECMO run patient recovered left ventricular function and patient was weaned from all mechanical support devices. But patient developed septic shock refractory to vasopressors therapy and patient died.
Source: The Egyptian Journal of Critical Care Medicine - Category: Intensive Care Source Type: research

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Authors: Tran SL, Porrini C, Ramarao N Abstract Nitric oxide (NO) is present in various organisms from humans, to plants, fungus and bacteria. NO is a fundamental signaling molecule implicated in major cellular functions. The role of NO ranges from an essential molecule to a potent mediator of cellular damages. The ability of NO to react with a broad range of bio molecules allows on one hand its regulation and a gradient concentration and on the other hand to exert physiological as well as pathological functions. In humans, NO is implicated in cardiovascular homeostasis, neurotransmission and immunity. However, NO ...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Conclusions: Axillary reverse mapping is a minimally invasive technique that can be performed during axillary lymph-node dissection, helping to prevent the subsequent development of arm lymphedema. Trial registration: #SCURCTN3276, retrospectively registered on 11 April 2017 at Research Ethics Committee at the Faculty of medicine-Suez Canal University. PMID: 31807140 [PubMed]
Source: Patient Safety in Surgery - Category: Surgery Authors: Tags: Patient Saf Surg Source Type: research
What happens in Exodus 34 is very strange indeed. You may remember that Moses broke the tablets with the Ten Commandments because he was pissed off about the golden calf and all that. So God calls him back up the mountain to get a new set. Only -- they're completely different.34 TheLord said to Moses, “Cut two tablets of stone like the former ones, and I will write on the tablets the words that were on the former tablets, which you broke.2 Be ready in the morning, and come up in the morning to Mount Sinai and present yourself there to me, on the top of the mountain.3 No one shall come up with you, and ...
Source: Stayin' Alive - Category: American Health Source Type: blogs
Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway. Med Sci Monit. 2019 Dec 06;25:9290-9298 Authors: Shang X, Lin K, Yu R, Zhu P, Zhang Y, Wang L, Xu J, Chen K Abstract BACKGROUND Sepsis combined with myocardial injury is an important cause of septic shock and multiple organ failure. However, the molecular mechanism of sepsis-induced myocardial dysfunction has not yet been thoroughly studied. Resveratrol has been an important rese...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Coates TD Abstract Before the advent of effective iron chelation, death from iron-induced cardiomyopathy occurred in the second decade in patients with transfusion-dependent chronic anemias. The advances in our understanding of iron metabolism; the ability to monitor iron loading in the liver, heart, pancreas and pituitary; and the availability of several effective iron chelators have dramatically improved survival and reduced morbidity from transfusion-related iron overload. Nevertheless, significantly increased survival brings about new complications such as malignant transformation resulting from prolon...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
ConclusionsSpontaneous reperfusion prior to pPCI in STEMI was associated with a lower risk of adverse clinical events. These exploratory data from a targeted discovery proteomics platform identifies novel proteins across diverse, yet complementary, pathobiological axes that show promise in providing mechanistic insights into spontaneous reperfusion in STEMI.Condensed abstractSpontaneous reperfusion has been established with improved STEMI outcomes, yet its pathobiology is unclear and appears to involve diverse physiological processes. Using a 91-biomarker high-throughput proteomics platform, we studied 683 STEMI patients i...
Source: American Heart Journal - Category: Cardiology Source Type: research
AbstractWe recently reported low-density lipoprotein receptor-related protein 6 (LRP6) decreased in dilated cardiomyopathy hearts, and cardiac-specific knockout mice displayed lethal heart failure through activation of dynamin-related protein 1 (Drp1). We also observed lipid accumulation in LRP6 deficiency hearts, but the detailed molecular mechanisms are unclear. Here, we detected fatty acids components in LRP6 deficiency hearts and explored the potential molecular mechanisms. Fatty acid analysis by GC-FID/MS revealed cardiac-specific LRP6 knockout induced the higher level of total fatty acids and some medium-long-chain f...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
This study examined the association of preoperative serum albumin with outcomes for laparoscopic cholecystectomy.MethodsThe American College of Surgeons National Surgical Quality Improvement Program was retrospectively analyzed from 2005-2016 for adult patients undergoing laparoscopic cholecystectomy. Patients were stratified into four groups:
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Conclusions: Intensivists should be aware of this rare but rapid complication on extracorporeal membrane oxygenation support that may directly impact outcome. The precise role of extracorporeal membrane oxygenation support in the timing and frequency of new-onset diffuse myocardial calcification deserves further investigation.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Case Report Source Type: research
Abstract A 24‐year‐old female presented with sepsis and cardiogenic shock 4 days after vaginal delivery. Veno‐arterial extracorporeal membrane oxygenation (VA ECMO) therapy was used for cardiovascular support as a bridge for recovery. The use of VA ECMO in patients with cardiogenic shock secondary to sepsis is reviewed.
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CASE REPORT Source Type: research
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