Human breast cancer xenograft model implicates peroxisome proliferator-activated receptor signaling as driver of cancer-induced muscle fatigue.

CONCLUSIONS: Collectively, these data demonstrate that the BC-PDOX model recapitulates the expected BC-induced SkM fatigue and further identify aberrant PPAR signaling as an integral factor in the pathology of this condition.
PMID: 30559167 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - December 17, 2018 Category: Cancer & Oncology Authors: Wilson HE, Rhodes KK, Rodriguez D, Chahal I, Stanton DA, Bohlen J, Davis M, Infante AM, Hazard-Jenkins H, Klinke DJ, Pugacheva EN, Pistilli EE Tags: Clin Cancer Res Source Type: research