Insertional translocation involving an additional nonchromothriptic chromosome in constitutional chromothripsis: Rule or exception?

ConclusionOur findings show that (a) both simple and complex unbalanced rearrangements may result by the recombination of a cryptic parental balanced chromothripsis and that (b) insertional translocations are the spy of more complex rearrangements and not simply a three ‐breakpoint event.

https://onlinelibrary.wiley.com/doi/abs/10.1002/mgg3.496?af=R

Source: Molecular Genetics & Genomic Medicine - December 18, 2018 Category: Genetics & Stem Cells Authors: Nehir Edibe Kurtas, Luciano Xumerle, Ursula Giussani, Alessandra Pansa, Laura Cardarelli, Veronica Bertini, Angelo Valetto, Thomas Liehr, Maria Clara Bonaglia, Edoardo Errichiello, Massimo Delledonne, Orsetta Zuffardi Tags: ORIGINAL ARTICLE Source Type: research