Recent preparative applications of redox enzymes.

Recent preparative applications of redox enzymes.
Curr Opin Chem Biol. 2018 Dec 12;49:105-112
Authors: Prier CK, Kosjek B
Abstract
Redox enzymes offer many powerful transformations for the efficient industrial-scale synthesis of diverse chemicals desired by society. Here we survey recent preparative applications of redox enzymes, highlighting both mature enzyme platforms and promising technologies for future applications. While in some cases commercial enzymes can be employed directly on industrial scales, in other cases protein engineering is necessary to evolve an enzyme fit for non-biological substrates and conditions. Both approaches require the input of process engineering to properly balance the needs of the enzymatic chemistry with the requirements for an industrial process. A convergence of advances in enzyme discovery, protein engineering, and process engineering is expected to fuel a more rapid development of enzymatic synthetic processes and a wider adoption of biocatalysis on industrial scales.
PMID: 30554005 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - December 12, 2018 Category: Biochemistry Authors: Prier CK, Kosjek B Tags: Curr Opin Chem Biol Source Type: research