Histologic similarities in children with eosinophilic esophagitis and proton pump inhibitor –responsive esophageal eosinophilia

Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and proton pump inhibitor (PPI)-responsive esophageal eosinophilia (PPI-REE) is difficult because symptoms overlap and there is no pathognomonic histologic feature for these disorders.1 Current EoE diagnostic guidelines define EoE as a clinicopathological condition characterized by symptoms of esophageal dysfunction and greater than 15 eosinophils per hpf (eos/hpf) in the esophageal mucosa after ruling out other etiologies as a cause of inflammation.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research