CNOT6L couples the selective degradation of maternal transcripts to meiotic cell cycle progression in mouse oocyte

This study provides the first direct genetic evidence that CCR4–NOT-dependent and particularly CNOT6L-dependent decay of selective maternal mRNAs is a prerequisite for meiotic maturation of oocytes.

Source: EMBO Journal - December 14, 2018 Category: Molecular Biology Authors: Sha, Q.-Q., Yu, J.-L., Guo, J.-X., Dai, X.-X., Jiang, J.-C., Zhang, Y.-L., Yu, C., Ji, S.-Y., Jiang, Y., Zhang, S.-Y., Shen, L., Ou, X.-H., Fan, H.-Y. Tags: Cell Cycle, Development & Differentiation, RNA Biology Articles Source Type: research