Inflammatory Bowel Disease, Prostate Cancer Linked

WEDNESDAY, Dec. 12, 2018 -- Men with inflammatory bowel disease (IBD) have an increased risk for prostate cancer (PCa), according to a study published online Dec. 4 in European Urology. Jacob A. Burns, from the Northwestern University Feinberg...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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Publication date: Available online 20 July 2019Source: BurnsAuthor(s): Sarvnaz Sepehripour, Elizabeth Chipp
Source: Burns - Category: Dermatology Source Type: research
Publication date: Available online 20 July 2019Source: Seminars in Cancer BiologyAuthor(s): Nancy A. Espinoza-Sánchez, Martin GötteAbstractOver the past few decades, understanding how tumor cells evade the immune system and their communication with their tumor microenvironment, has been the subject of intense investigation, with the aim of developing new cancer immunotherapies. The current therapies against cancer such as monoclonal antibodies against checkpoint inhibitors, adoptive T-cell transfer, cytokines, vaccines, and oncolytic viruses have managed to improve the clinical outcome of the patients. However,...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
DiscussionWe estimated higher risks of ALL in the offspring of women with pregestational diabetes. These results are consistent with previous findings and compatible with a role of prenatal glycaemic environment in childhood cancer aetiology.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 20 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Ashlynn L.Z. Lee, Chuan Yang, Shujun Gao, James L. Hedrick, Yi Yan YangAbstractProlonged vaccine release enables gradual immunostimulation, providing long-term immunity. Herein, Vitamin E- PEG-Vitamin E triblock ‘ABA’ hydrogel, which is formed through physical cross-linking of flower-shaped micelles and can reside in vivo for>17 weeks, was employed for delivery of cancer preventive vaccines to provide sustained anticancer immunity. Mice vaccinated with hydrogel formulations produced a sign...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 20 July 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Samaneh Kabirian-Dehkordi, Mounira Chalabi-Dchar, Hichem C Mertani, Dominique Le Guellec, Bernard Verrier, Jean-Jacques Diaz, Masoud A. Mehrgardi, Philippe BouvetAbstractG-rich oligonucleotide, AS1411, has been shown to interact with nucleolin and to inhibit cancer cell proliferation and tumor growth. This antiproliferative action is increased when AS1411 is conjugated to different types of nanoparticles. However, the molecular mechanisms are not known. In this work, we show in several cell lines that optimiz...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 20 July 2019Source: NeurocomputingAuthor(s): Yan Li, Lu Wang, Jiayu Zhou, Jieping YeAbstractThere are many major diseases that remain incurable, such as cancer and Alzheimer’s disease (AD). Therefore, the prevention for these diseases has more impact than diagnosis and treatment. Survival analysis aims at predicting the time of occurrence of specific events of interest. It can be used to identify patients of high risk, which helps healthcare system effectively allocate limited medical resources. In many real-world applications, such as healthcare analysis, a lot of datasets are coll...
Source: Neurocomputing - Category: Neuroscience Source Type: research
ConclusionsAt-risk smokers in Virginia, particularly those living in rural areas with high smoking rates, do not have adequate recommended LDCT coverage. More screening centers are needed to care for the high number of rural smokers at risk for lung cancer.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 1 June 2019Source: European UrologyAuthor(s): Zeynep G. Gul, Alberto Martini, Carl A. Olsson
Source: European Urology - Category: Urology & Nephrology Source Type: research
Publication date: Available online 28 May 2019Source: European UrologyAuthor(s): Jacob A. Burns, Adam B. Weiner, Shilajit Kundu
Source: European Urology - Category: Urology & Nephrology Source Type: research
IBD as a risk factor for prostate cancer: what is the link?, Published online: 11 February 2019; doi:10.1038/s41585-019-0157-7Chronic inflammation in the prostate is a suspected risk factor for prostate cancer. Burns and colleagues implicate chronic inflammation in prostate cancer development, albeit from an unexpected source — the gastrointestinal tract. This new study implicates a history of inflammatory bowel disease with an increased risk of a prostate cancer diagnosis.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research
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