Rates of lymph node invasion and their impact on cancer specific mortality in upper urinary tract urothelial carcinoma

Publication date: Available online 11 December 2018Source: European Journal of Surgical OncologyAuthor(s): Sebastiano Nazzani, Elio Mazzone, Felix Preisser, Zhe Tian, Francesco A. Mistretta, Shahrokh F. Shariat, Emanuele Montanari, Pietro Acquati, Alberto Briganti, Fred Saad, Luca Carmignani, Pierre I. KarakiewiczAbstractPurposeTo analyze lymph node invasion (LNI) rates according to tumor characteristics and to test the impact of LNI and its extent on cancer specific mortality (CSM) in surgically-treated non metastatic urothelial upper urinary tract carcinoma (UTUC) patients.Materials and methodsWithin the SEER database (2004–2014), we identified 2098 patients with histologically confirmed non-metastatic urothelial carcinoma of renal pelvis or ureter who underwent NU with LND. LNI rates stratified according to tumor location and stage were described. Kaplan-Meier plots illustrated CSM rates according to LNI and its extent. Multivariable Cox regression models (MCRMs) tested the effect of LNI and its extent on CSM.ResultsOf 2098 UTUC patients, who underwent nephroureterectomy with lymph node dissection, 646 (33%) had LNI. The median number of removed lymph nodes was 3 [Interquartile range (IQR): 1–7]. The median number of positive lymph nodes in patients, who harbored LNI was 1 (IQR:1–3). LNI rates according to tumor location were, respectively, 23.6% for ureteral and 36.5% for renal pelvis tumors. LNI rates according to tumor stage were 9.6, 18.0, 38.7 and 63...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research

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Source: Toxicology - Category: Toxicology Authors: Tags: Toxicology Source Type: research
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Source: The American Journal of Surgical Pathology - Category: Pathology Tags: Special Article Source Type: research
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Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Source Type: research
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Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
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Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Pharm Ther Source Type: research
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Source: Gynecologic Oncology - Category: Cancer & Oncology Authors: Tags: Gynecol Oncol Source Type: research
Conditions:   Carcinoma;   Transitional Cell Carcinoma;   Transitional Cell Cancer of the Renal Pelvis and Ureter Intervention:   Drug: UGN-101 instillations Sponsor:   UroGen Pharma Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
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Source: Actas Urologicas Espanolas - Category: Urology & Nephrology Authors: Tags: Actas Urol Esp Source Type: research
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