Impact of a multimodal strategy combining a new standard of care and restriction of carbapenems, fluoroquinolones and cephalosporins, on antibiotic consumption and resistance of P.aeruginosa in an ICU

Antibiotic-resistant bacteria cause hospital epidemics and are associated with therapeutic failures and an increased morbidity and mortality [1,2]. Mastering the consumption of antibiotics is a critical point since the link between the use of antibiotics and the emergence of antibiotic resistance has been well established, particularly in intensive care units (ICUs) where broad-spectrum antibiotics are frequently prescribed [3,4]. Especially, quinolones, cephalosporins and carbapenems are said to have a high “ecologic impact”, by favoring the selection of drug-resistant bacteria to both the antibiotic used and other classes of antibiotics, as well as the emergence of colonization to drug-resistant organisms [5,6].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research