Cyclic sulfur-containing compounds from Allium fistulosum ‘Kujou’

AbstractSulfur-containing compounds, allicin and ajoene, etc., were isolated fromAllium species. In a recent study, some sulfur-containing cyclic compounds were isolated fromA. sativum,A. cepa, andA. fistulosum. Four new compounds with multiple rings with methyl disulfide or propyl disulfide at the side chain of the 7-position, kujounins A3 (1), B1 (2), B2 (3) and B3 (4), and two new thiolane type compounds with methoxy and methyl sulfoxide moiety at the 2- and 5-positions, and allium sulfoxides A2 (5) and A3 (6), were isolated from the acetone extract of the fresh white parts ofAllium fistulosum‘Kujou’ with three known compounds, kujounin A1 (7) and A2 (8), and allium sulfoxide A1 (9). The chemical structures of the new compounds were elucidated on the basis of physicochemical evidence. The kujounins had a rare molecular skeleton, which was tetrahydro-2H-difuro[3,2-b:2 ′,3′-c]furan-5(5aH)-one.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research