Awakening p53 in vivo by D-peptides-functionalized ultra-small nanoparticles: Overcoming biological barriers to D-peptide drug delivery

Conclusion: The present study not only sheds light on the development of AuNP-DPA as a novel class of antitumor agents for drugging the p53 pathway in vivo, but also supplies a new strategy to use D-peptides as intracellular PPI inhibitors for cancer-targeted therapy.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Zhenyuan Bian, Jin Yan, Simeng Wang, Yijie Li, Yi Guo, Bohan Ma, Hao Guo, Zhijie Lei, Chun Yin, Yi Zhou, Min Liu, Kaishan Tao, Peng Hou, Wangxiao He Tags: Research Paper Source Type: research