Islet α -cell Inflammation Induced By NF- κ B inducing kinase (NIK) Leads to Hypoglycemia, Pancreatitis, Growth Retardation, and Postnatal Death in Mice

Conclusions: Islet α-cell specific overexpression of NIK results in islet α-cell dysfunction and causes islet β-cell death and pancreatitis, which are most likely due to paracrine secretion of cytokines and chemokines from islet α cells, thus leading to hypoglycemia, growth retardation, and postnatal death in mice.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Xinzhi Li, Linna Jia, Xiaoyue Chen, Ying Dong, Xiaomeng Ren, Yuefan Dong, Ying Chen, Liwei Xie, Ming Liu, Chiyo Shiota, George K. Gittes, Liangyou Rui, Zheng Chen Tags: Research Paper Source Type: research