Investigators on the Path to Alzheimer ’s Detection Test
Brigham and Womenâs Hospital investigators are working on a test that could either diagnose or predict Alzheimerâs disease before symptoms appear. The investigators approach is in the December issue of Alzheimerâs & Dementia.
Tau proteins have long been a calling card for Alzheimerâs disease. But the issue is tau occurs as a family of related molecules which have subtly different properties. Investigators took this into consideration and built assays to measure the different forms of tau. The team identified a subset of tau proteins which are specifically elevated in Alzheimerâs disease.
The Brigham and Womenâs Hospital investigators analyzed five different tests for tau fragments, finding that one, known as the NT1 assay, showed sufficient diagnostic sensitivity (the ability to predict AD cases) and specificity (the ability to exclude controls) to pursue its use as a potential screening tool for Alzheimer's disease. Researchers said this was confirmed in both sets of patients.
"We've made our data and the tools needed to perform our test widely available because we want other research groups to put this to test," corresponding author Dominic Walsh, PhD, of the Ann Romney Center for Neurologic Diseases at the Brigham, said in a release. "It's important for others to validate our findings so that we can be certain this test will work across different pop...
Source: MDDI - Category: Medical Devices Authors: Omar Ford Tags: IVD Source Type: news