Effects of Codonopis bulleynana Forest ex Diels on Deferribacteres in constipation predominant intestine tumor: differential analysis

Publication date: Available online 6 December 2018Source: Saudi Journal of Biological SciencesAuthor(s): Yunpeng Luan, Yanmei Li, Xiaoguan Yue, Fei Xiang, Dechang Mao, Yong Cao, Zhi XiongAbstractAs a complicated micro-ecosystem, gut microbes are closely related to metabolic disease, immune disease and tumor (such as constipation. Long- term constipation would cause intestinal mucosal injury, enteritis, ileus, etc., thus inducing intestine cancer). In this research, intestine cancer model group and Codonopsis foetens treatment group were successfully constructed, and the variation of intestinal microbes were analyzed by 16S rRNA sequence. Results showed that there were changes in bacteria abundance of Firmicutes, Bacteroidetes, Proteobacteria, Deferribacteres, Tenericutes, and Actinobacteria, etc. Codonopsis foetens could directly or indirectly affect the growth and metabolism of Deferribacteres by altering the nutritional ingredient and pH value of intestine “medium”, thus affecting the occurrence and development of intestinal microbes.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research