Airway and systemic oxidant-antioxidant dysregulation in asthma: A possible scenario of oxidants spill over from lung into blood

Publication date: October 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 1 Author(s): A. Nadeem , N. Siddiqui , Naif O. Alharbi , Mohamed M. Alharbi Asthma is characterized by repeated episodes of airway obstruction and an ongoing cycle of airway inflammation. Reactive oxygen species (ROS) produced by inflammatory cells in the lung play a key role in the pathogenesis as well as amplification of inflammation in asthmatic airways. Several enzymatic and non-enzymatic antioxidants are available in the lung and systemic circulation to counteract ROS-mediated damage on various biomolecules such as lipid membranes, proteins, and DNA; however during asthmatic inflammation these defenses are overwhelmed due to excessive production of ROS thereby leading to inflammatory events in the airways/systemic circulation. ROS-mediated damage may result in increased vascular permeability, mucus hypersecretion, smooth muscle contraction, epithelial shedding and impairment in the responsiveness of β-adrenergic receptors. Strategies aimed to boost the endogenous antioxidants either through dietary or pharmacological intervention to redress oxidant-antioxidant imbalance in asthma is the current area of research in many laboratories throughout the world. This review aims at providing a comprehensive overview of the available literature on oxidative stress and antioxidants imbalance in asthma with a focus both on lung and blood components and bring forth correlations be...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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CONCLUSIONS: Both industrial- and traffic-related air pollution have a negative effect on asthma risk in young males. Studies evaluating the association between asthma risk and specific air pollutants (e.g., sulfur dioxide, particulate matter, and nitrogen dioxide) are needed to ascertain the effects of individual air pollutants on asthma occurrence. PMID: 31814340 [PubMed - in process]
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
Publication date: Available online 11 December 2019Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Eleonora Di Salvo, Vincenzo Patella, Marco Casciaro, Sebastiano GangemiAbstractMontelukast the leukotriene receptor antagonist is an anti-inflammatory drug that causes bronchodilation and for this reason it is used to improve inflammatory states in asthma and allergic rhinitis. Montelukast is generally considered a safe drug with the occurrence of a few adverse drug reactions (ADRs) and anti-leucotrienes are usually well-tolerated by adults and young patients. Starting from these premises the purpose of this review...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
The editors and staff of the Annals of Allergy, Asthma and Immunology would like to thank the flowing individuals who gave of their time to provide reviews of submitted manuscripts between January 1 and June 30, 2019. The high-quality manuscript reviews provided by these individuals is essentially to the peer review process so necessary for a journal like ours to provide scientifically sound as well as interesting and engaging articles for our readers. Thanks to each of you for your service.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Source Type: research
Recent studies have highlighted the multidimensional effect of atopic dermatitis (AD) and urticaria. Patient burden for these conditions is largely driven by the intense itching, sleep disturbance, comorbidities, and mental health illness associated with these diseases.1-3 Immunologic, microbial, and epithelial interactions have been reported to play an important role in AD.4,5 Novel therapies and management approaches are targeting the mechanisms underlying AD and urticaria.6,7 The current issue of the Annals contains 3 outstanding reviews that update readers on the pathophysiology and evolving treatments for AD and chronic urticaria.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Editorial Source Type: research
Mepolizumab may be an effective treatment option for patients with severe asthma and underlying eosinophilic chronic rhinosinusitis.BMC Pulmonary Medicine
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Pulmonary Medicine Journal Article Source Type: news
Abstract Rhinoconjunctivitis is a public health problem that causes major illness and disability worldwide. Epidemiological studies intended to determine the burden of rhinoconjunctivitis in Kuwait are limited. Hence, this study sought to estimate the prevalence of rhinoconjunctivitis among adolescents in Kuwait and explore its association with different risk factors. Schoolchildren aged 11-14 years (n = 3,864) were enrolled in a cross-sectional study. Parents completed questionnaires regarding their children's clinical history and symptoms of rhinoconjunctivitis and relevant exposures. Associations ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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