The protease ‐activated receptor 4 Ala120Thr variant alters platelet responsiveness to low‐dose thrombin and protease‐activated receptor 4 desensitization, and is blocked by non‐competitive P2Y12 inhibition

ConclusionTheF2RL3 rs773902 SNP alters platelet reactivity to thrombin; the allelic effect requires P2Y12, and is not affected by gender. Ticagrelor blocks the enhanced reactivity of rs773902 A platelets. PAR4 encoded by the rs773902 A allele is relatively resistant to desensitization and may contribute to stroke risk.

Source: Journal of Thrombosis and Haemostasis - November 22, 2018 Category: Hematology Authors: M. J. Whitley, D. M. Henke, A. Ghazi, M. Nieman, M. Stoller, L. M. Simon, E. Chen, J. Vesci, M. Holinstat, S. E. McKenzie, C. A. Shaw, L. C. Edelstein, P. F. Bray Tags: Original Article Source Type: research