SEC14L2, a lipid-binding protein, regulate HCV replication in culture with inter- and intra- genotype variations

Hepatitis C virus (HCV) is a positive stranded RNA Hepacivirus in the Flaviviridae family. Today, HCV remains an important element in the aetiology of chronic liver disease and according to the World Health Organisation there are estimated 71 million chronically infected patients worldwide [1]. Since the virus discovery in 1989, the development of tools such as a subgenomic replicon system, cell culture adapted variants and highly permissive hepatoma cell lines have enabled researchers to study different aspects of the HCV life cycle.

Source: Journal of Hepatology - November 22, 2018 Category: Gastroenterology Authors: Rui Costa, Daniel Todt, Francisco Zapatero-Belinch ón, Christian Schenk, Olympia E. Anastasiou, Andreas Walker, Barbara Hertel, Lejla Timmer, Denisa Bojkova, Maren Ruckert, Christoph Sarrazin, Jörg Timm, Volker Lohmann, Michael P. Manns, Eike Steinman, Source Type: research