A Physiologically Based Pharmacokinetic Model for Optimally Profiling Lamotrigine Disposition and Drug –Drug Interactions

ConclusionsOur developed PBPK lamotrigine profile accurately predicts DDIs and lamotrigine IR/XR formulation disposition in adults and children. This PBPK model will be helpful in designing future DDI studies for co-administration of lamotrigine with other drugs and in designing individualized patient dosing regimens.

http://link.springer.com/10.1007/s13318-018-0532-4

Source: European Journal of Drug Metabolism and Pharmacokinetics - November 20, 2018 Category: Drugs & Pharmacology Source Type: research