Associations of Multiple NOTCH4 Exonic Variants with Systemic Sclerosis.

CONCLUSION: Multiple NOTCH4 exonic variants were associated with SSc and/or SSc subtypes. Several of these variants encode nonsynonymous sequence changes occurring in the NECD, which implicates a potentially functional effect of NOTCH4.
PMID: 30442821 [PubMed - as supplied by publisher]

Source: J Rheumatol - November 15, 2018 Category: Rheumatology Authors: Zhou X, Li H, Guo S, Wang J, Shi C, Espitia M, Guo X, Wang Q, Liu M, Assassi S, Reveille JD, Mayes MD Tags: J Rheumatol Source Type: research