Complement component 5 does not interfere with physiologic hemostasis but is essential for Escherichia coli ‐induced coagulation accompanied by Toll‐like receptor 4

In conclusion, C5 showed no impact on physiological hemostasis, but substantially contributed toE.coli‐induced procoagulant events, which were abolished by the combined inhibition of C5 and CD14 or TLR4.This article is protected by copyright. All rights reserved.

Source: Clinical and Experimental Immunology - November 16, 2018 Category: Allergy & Immunology Authors: Anne Landsem, Hilde Fure, Judith Krey Ludviksen, Dorte Christiansen, Corinna Lau, Monica Mathisen, Grethe Bergseth, Stig Nymo, Knut Tore Lappeg ård, Trent Martin Woodruff, Terje Espevik, Tom Eirik Mollnes, Ole‐Lars Brekke Tags: Original Article Source Type: research